Double-activation of mitochondrial permeability transition pore opening via calcium overload and reactive oxygen species for cancer therapy

Double-activation of mitochondrial permeability transition pore opening via calcium overload and reactive oxygen species for cancer therapy

Background: Calcium ions (Ca2+) participates in various intracellular signal cascades and especially plays a key role in pathways relevant to cancer cells. Mitochondrial metabolism stimulated by calcium overload can trigger the opening of the mitochondrial permeability transition pore (MPTP), which...

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Bibliographic Details
Main Authors: Cai, L. (Author), Jing, S. (Author), Liu, S. (Author), Pang, M. (Author), Shen, X. (Author), Zhao, Y. (Author), Zhou, Y. (Author), Zhu, C. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
Activation analysis
Ca 2+
Ca2+ overload
Calcite
Calcium
Calcium carbonate
Calcium overload
Cancer cells
Cell death
Chemical activation
Covalent organic frameworks
Diseases
Double activation
Hypoxia
Iron compounds
Mammals
Mitochondria
Mitochondrial permeability transition pore
MPTP
Oncology
Oxygen
Photodynamic therapy
Reactive oxygen species
Tumor microenvironments
Tumors
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