Phosphorylated ATF1 at Thr184 promotes metastasis and regulates MMP2 expression in gastric cancer

Phosphorylated ATF1 at Thr184 promotes metastasis and regulates MMP2 expression in gastric cancer

Background: Studies have revealed an important role of activating transcription factor 1 (ATF1) and phosphorylated ATF1 at Ser63 in tumors. Our previous study identified Thr184 as a novel phosphorylation site of ATF1. However, the role of phosphorylated ATF1 at Thr184 (p-ATF1-T184) in tumor is uncle...

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Bibliographic Details
Main Authors: Cao, H. (Author), Ding, J. (Author), He, Z. (Author), Huang, G.-L (Author), Li, T. (Author), Wang, F. (Author), Wang, J. (Author), Wu, S. (Author), Zhong, P. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
activating transcription factor 1
Activating Transcription Factor 1
Adaptor Proteins, Signal Transducing
ATF1
Cell Line, Tumor
cell motion
Cell Movement
Gastric cancer
gelatinase A
gene expression regulation
Gene Expression Regulation, Neoplastic
genetics
human
Humans
LRBA protein, human
Matrix Metalloproteinase 2
messenger RNA
metabolism
MMP2
MMP2 protein, human
pathology
Phosphorylation
prognosis
Prognosis
RNA, Messenger
signal transducing adaptor protein
Stomach Neoplasms
stomach tumor
tumor cell line
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