Melanocortin 1 receptor activation protects against alpha-synuclein pathologies in models of Parkinson’s disease

Melanocortin 1 receptor activation protects against alpha-synuclein pathologies in models of Parkinson’s disease

Background: Epidemiological studies suggest a link between the melanoma-related pigmentation gene melanocortin 1 receptor (MC1R) and risk of Parkinson’s disease (PD). We previously showed that MC1R signaling can facilitate nigrostriatal dopaminergic neuron survival. The present study investigates th...

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Bibliographic Details
Main Authors: Cai, W. (Author), Chen, X. (Author), Feng, D. (Author), Fisher, D.E (Author), Frosch, M.P (Author), Lin, Y. (Author), Mclean, P. (Author), Schwarzschild, M.A (Author), Srivastava, P. (Author), Vanderburg, C.R (Author), Xu, Y. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
alpha synuclein
Alpha-synuclein
animal cell
animal experiment
animal model
animal tissue
Article
bms 470539
controlled study
disease exacerbation
dopaminergic nerve cell
gene activation
gene interaction
gene mutation
gene overexpression
human
human cell
human tissue
in vitro study
male
MC1R gene
melanocortin 1 receptor
Melanocortin 1 receptor
Melanoma
mesencephalon
mouse
ndp msh
nervous system inflammation
neuroprotection
neuroprotective agent
nigroneostriatal system
nonhuman
Nuclear factor erythroid 2-related factor 2
Parkinson disease
Parkinson’s disease
pathogenesis
protein function
substantia nigra
tissue level
transcription factor Nrf2
transgene
unclassified drug
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