Multimarker synaptic protein cerebrospinal fluid panels reflect TDP-43 pathology and cognitive performance in a pathological cohort of frontotemporal lobar degeneration

Multimarker synaptic protein cerebrospinal fluid panels reflect TDP-43 pathology and cognitive performance in a pathological cohort of frontotemporal lobar degeneration

Background: Synapse degeneration is an early event in pathological frontotemporal lobar degeneration (FTLD). Consequently, a surrogate marker of synapse loss could be used to monitor early pathologic changes in patients with underlying FTLD. The aim of this study was to evaluate the relationship of...

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Main Authors: Alcolea, D. (Author), Belbin, O. (Author), Cervantes González, A. (Author), Chen-Plotkin, A. (Author), Dols-Icardo, O. (Author), Fortea, J. (Author), Grossman, M. (Author), Illán-Gala, I. (Author), Irwin, D.J (Author), Lee, E.B (Author), Lleó, A. (Author), McMillan, C.T (Author), Querol-Vilaseca, M. (Author), Santos-Santos, M.A (Author), Sirisi, S. (Author), Trojanowski, J.Q (Author), Wolk, D. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
biological marker
Biomarker
Biomarkers
Calsyntenin-1
cerebrospinal fluid
Cerebrospinal fluid
cognition
Cognition
DNA binding protein
DNA-Binding Proteins
frontotemporal dementia
Frontotemporal dementia
Frontotemporal Dementia
Frontotemporal lobar degeneration
Frontotemporal Lobar Degeneration
human
Humans
pathology
Tau
tau protein
tau Proteins
TDP-43
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