Identification of distinct slow mode of reversible adaptation of pancreatic ductal adenocarcinoma to the prolonged acidic pH microenvironment

Identification of distinct slow mode of reversible adaptation of pancreatic ductal adenocarcinoma to the prolonged acidic pH microenvironment

Background: Pancreatic ductal adenocarcinoma (PDAC) is the most common pancreatic neoplasm with high metastatic potential and poor clinical outcome. Like other solid tumors, PDAC in the early stages is often asymptomatic, and grows very slowly under a distinct acidic pHe (extracellular pH) microenvi...

Full description

Bibliographic Details
Main Authors: Chang, C.-R (Author), Chang, W.-S.W (Author), Chen, L.-T (Author), Chen, T.-H (Author), Jiang, S.-S (Author), Liao, C.-Y (Author), Lin, K.M.-C (Author), Lu, W.-C (Author), Tsai, F.-Y (Author), Wu, T.-C (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
Acidic stress
acidosis
Acidosis
adaptation
Adaptation, Physiological
Autophagy
Carcinoma, Pancreatic Ductal
Cell Line, Tumor
Extracellular pH
Fission
Fusion
gene expression regulation
Gene Expression Regulation, Neoplastic
genetics
human
Humans
Hydrogen-Ion Concentration
metabolism
Mitochondrial dynamics
pancreas carcinoma
pancreas tumor
pancreatic duct
Pancreatic ductal adenocarcinoma
Pancreatic Ducts
Pancreatic Neoplasms
pathology
pH
tumor cell line
tumor microenvironment
Tumor microenvironment
Tumor Microenvironment
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items