Genome-scale CRISPR screens identify host factors that promote human coronavirus infection

Genome-scale CRISPR screens identify host factors that promote human coronavirus infection

Background: The COVID-19 pandemic has resulted in 275 million infections and 5.4 million deaths as of December 2021. While effective vaccines are being administered globally, there is still a great need for antiviral therapies as antigenically novel SARS-CoV-2 variants continue to emerge across the...

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Bibliographic Details
Main Authors: Bluhm, A.P (Author), Grodzki, M. (Author), Karst, S.M (Author), Norris, M.H (Author), Rafiee, R. (Author), Russo, M. (Author), Schaefer, M. (Author), Sobh, A. (Author), Tagmount, A. (Author), Vulpe, C.D (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
abemaciclib
airway epithelium cell
amlexanox
angiotensin converting enzyme 2
animal
animal cell
Animals
antiviral activity
Antiviral Agents
antivirus agent
Article
CCZ1 gene
cell cycle regulation
Chlorocebus aethiops
chlorpromazine
cid 1067700
clustered regularly interspaced short palindromic repeat
Clustered Regularly Interspaced Short Palindromic Repeats
controlled study
copy number variation
Coronavirinae
coronavirus disease 2019
COVID-19
cyclin dependent kinase inhibitor
drug effect
drug research
drug therapy
ectopic expression
EDC4 gene
EDC4 protein, human
exoribonuclease
Exoribonucleases
gene
gene editing
Gene Editing
gene function
gene silencing
genetic analysis
genetics
Genome, Viral
guide RNA
harmine
HEK293 cell line
HEK293 Cells
host pathogen interaction
Host-Pathogen Interactions
human
human cell
Human coronavirus OC43
Humans
immune response
in vitro study
infection resistance
messenger RNA
metabolism
microtubule associated protein
Microtubule-Associated Proteins
nintedanib
nonhuman
olaparib
pathology
physiology
procedures
promethazine
protein
protein inhibitor
Proteins
reverse transcription polymerase chain reaction
RNA interference
RNA Interference
RNA, Guide
RNA, Small Interfering
SARS-CoV-2
scientific literature
Severe acute respiratory syndrome coronavirus 2
small interfering RNA
uc 2288
unclassified drug
Vero C1008 cell line
Vero cell line
Vero Cells
virology
virus cell interaction
virus genome
virus replication
Virus Replication
XRN1 protein, human
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