Chemically defined and small molecules-based generation of sinoatrial node-like cells

Chemically defined and small molecules-based generation of sinoatrial node-like cells

Background: Existing methods for in vitro differentiation of human pluripotent stem cells (hPSCs) into sinoatrial node-like cells (SANLCs) require complex and undefined medium constituents. This might hinder the elucidation of the molecular mechanisms involved in cardiac subtype specification and pr...

Full description

Bibliographic Details
Main Authors: Fan, W. (Author), Hou, X. (Author), Lan, F. (Author), Li, F. (Author), Liao, B. (Author), Liu, F. (Author), Ma, S. (Author), Wan, J. (Author), Xu, M. (Author), Yan, Y. (Author), Yang, C. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
cardiac muscle cell
cell differentiation
Cell Differentiation
Chemically defined medium
Differentiation
fibroblast growth factor
Fibroblast Growth Factors
genetics
glucose
Glucose
glycogen synthase kinase 3
Glycogen Synthase Kinase 3
Human pluripotent stem cells
induced pluripotent stem cell
Induced Pluripotent Stem Cells
lactic acid
Lactic Acid
metabolism
Myocytes, Cardiac
Signaling pathway
Sinoatrial Node
Sinoatrial node-like cells
sinus node
Small molecule
Wnt signaling
Wnt Signaling Pathway
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items