Every road leads to Rome: therapeutic effect and mechanism of the extracellular vesicles of human embryonic stem cell-derived immune and matrix regulatory cells administered to mouse models of pulmonary fibrosis through different routes

Every road leads to Rome: therapeutic effect and mechanism of the extracellular vesicles of human embryonic stem cell-derived immune and matrix regulatory cells administered to mouse models of pulmonary fibrosis through different routes

Background: Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease. Whether extracellular vesicles are effective in treating IPF and what is the optimal administrative route is not clear. Our previous studies have shown that immunity and matrix regulatory cells (IMR...

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Bibliographic Details
Main Authors: Dai, H. (Author), Gao, T. (Author), Hao, J. (Author), Li, Y. (Author), Liu, P. (Author), Song, D. (Author), Wang, C. (Author), Wang, L. (Author), Wang, Z. (Author), Wu, J. (Author), Yang, S. (Author), Zhao, X. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
animal
Animals
Biodistribution
bleomycin
Bleomycin
disease model
Disease Models, Animal
exosome
Extracellular vesicles
Extracellular Vesicles
fibrosing alveolitis
human
human embryonic stem cell
Human embryonic stem cells
Human Embryonic Stem Cells
Humans
Idiopathic Pulmonary Fibrosis
IMRC
Italy
mesenchymal stem cell
Mesenchymal stem cells
Mesenchymal Stem Cells
metabolism
Mice
mouse
Pulmonary fibrosis
Rome
Route of administration
tissue distribution
Tissue Distribution
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