Understanding the Link between Obesity and Severe COVID-19 Outcomes: Causal Mediation by Systemic Inflammatory Response

Understanding the Link between Obesity and Severe COVID-19 Outcomes: Causal Mediation by Systemic Inflammatory Response

Background: Obesity is an established risk factor for severe COVID-19 outcomes. The mechanistic underpinnings of this association are not well-understood. Objective: To evaluate the mediating role of systemic inflammation in obesity-associated COVID-19 outcomes. Methods: This hospital-based, observa...

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Bibliographic Details
Main Authors: Bassett, I.V (Author), Cao, T. (Author), Cheng, D. (Author), Clerkin, K.J (Author), Foulkes, A.S (Author), Gupta, A. (Author), He, W. (Author), Kim, E. (Author), Lu, F. (Author), Lubitz, S.A (Author), Lumish, H. (Author), Madhavan, M.V (Author), Meigs, J.B (Author), Qian, J. (Author), Reilly, M.P (Author), Selvaggi, C. (Author), Shinnick, D. (Author), Thaweethai, T. (Author), Triant, V.A (Author), Yan, J. (Author)
Format: Article
Language:English
Published: Endocrine Society 2022
Subjects:
adult
Adult
aged
Aged
Aged, 80 and over
aging
Aging
biomarkers
blood
Blood Sedimentation
C reactive protein
complication
COVID-19
C-Reactive Protein
epidemiology
erythrocyte sedimentation rate
female
Female
ferritin
Ferritins
fibrin degradation product
Fibrin Fibrinogen Degradation Products
fibrin fragment D
human
Humans
IL6 protein, human
inflammation
interleukin 6
Interleukin-6
leukocyte count
Leukocyte Count
male
Male
middle aged
Middle Aged
mortality
obesity
Obesity
risk factor
Risk Factors
SARS-CoV-2
severe disease
systemic inflammatory response syndrome
Systemic Inflammatory Response Syndrome
treatment outcome
Treatment Outcome
United States
very elderly
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