Identification of Rare Loss-of-Function Genetic Variation Regulating Body Fat Distribution

Identification of Rare Loss-of-Function Genetic Variation Regulating Body Fat Distribution

Context: Biological and translational insights from large-scale, array-based genetic studies of fat distribution, a key determinant of metabolic health, have been limited by the difficulty in linking predominantly noncoding variants to specific gene targets. Rare coding variant analyses provide grea...

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Bibliographic Details
Main Authors: Barroso, I. (Author), Bowker, N. (Author), Cai, L. (Author), Day, F.R (Author), Dong, L. (Author), Glastonbury, C.A (Author), Griffin, J.D (Author), Kerrison, N.D (Author), Koprulu, M. (Author), Langenberg, C. (Author), Li, C. (Author), Lotta, L.A (Author), Luan, J. (Author), Lucarelli, D.M.E (Author), McCarthy, M.I (Author), O'Rahilly, S. (Author), Patel, S. (Author), Perry, J.R.B (Author), Rocha, N. (Author), Saudek, V. (Author), Savage, D.B (Author), Scott, R.A (Author), Semple, R.K (Author), Small, K.S (Author), Stewart, I.D (Author), Van De Streek, M. (Author), Wareham, N.J (Author), Wheeler, E. (Author), Wittemans, L.B.L (Author), Zhao, Y. (Author)
Format: Article
Language:English
Published: Endocrine Society 2022
Subjects:
cardiometabolic risk
fat distribution
genetic variants
loss of function
UK Biobank
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