Effects of Wood Smoke Constituents on Mucin Gene Expression in Mice and Human Airway Epithelial Cells and on Nasal Epithelia of Subjects with a Susceptibility Gene Variant in Tp53

BACKGROUND: Exposure to wood smoke (WS) increases the risk for chronic bronchitis more than exposure to cigarette smoke (CS), but the underlying mechanisms are unclear. OBJECTIVE: The effect of WS and CS on mucous cell hyperplasia in mice and in human primary airway epithelial cells (AECs) was compa...

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Bibliographic Details
Main Authors:	Chu, H.W (Author), Fort, S. (Author), McDonald, J. (Author), Mebratu, Y. (Author), Petersen, H. (Author), Tassew, D. (Author), Tesfaigzi, Y. (Author)
Format:	Article
Language:	English
Published:	Public Health Services, US Dept of Health and Human Services 2022
Subjects:	adenosine triphosphate adult aged airway epithelium cell animal animal cell animal experiment animal model animal tissue Animals anion transport antiporter Antiporters arginine Article body mass bovine serum albumin bronchoscopy cell culture cell hyperplasia chronic bronchitis cigarette smoke clinical article cohort analysis controlled study cystic fibrosis transmembrane conductance regulator dimethyl sulfoxide dodecyl sulfate sodium eosin epidermal growth factor receptor Epithelial Cells epithelium cell female forced vital capacity formaldehyde gene gene expression Gene Expression genetic association genetic polymorphism genetics genomic DNA HEK293T cell line hematoxylin high performance liquid chromatography histone H2AX horseradish peroxidase human human cell human tissue Humans image analysis immunoblotting immunofluorescence immunoglobulin G immunohistochemistry lung Lung male mass spectrometry metabolism Mice mitogen activated protein kinase 1 mitogen activated protein kinase 3 morphometry mouse mRNA expression level mucin nonhuman nose epithelium oxalic acid paraformaldehyde pathology plasmid polyacrylamide gel electrophoresis polyvinylidene fluoride protein analysis protein expression protein function protein p53 questionnaire retrovirus vector saponin short hairpin RNA Slc26a9 protein, mouse smoke smoking sucrose Sulfate Transporters TP53 protein, human triton x 100 Tumor Suppressor Protein p53 Western blotting wood Wood
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Effects of Wood Smoke Constituents on Mucin Gene Expression in Mice and Human Airway Epithelial Cells and on Nasal Epithelia of Subjects with a Susceptibility Gene Variant in Tp53

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