Computational drug repurposing against SARS-CoV-2 reveals plasma membrane cholesterol depletion as key factor of antiviral drug activity

Computational drug repurposing against SARS-CoV-2 reveals plasma membrane cholesterol depletion as key factor of antiviral drug activity

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Comparing SARS-CoV-2 infection-induced gene expression signatures to drug treatment-induced gene expression signatures is a promising bioinformatic tool to repurpose existing drugs against SARS-CoV-2. The general hypothesis of signature-based drug repurposing is that drugs with inverse similarity to...

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Bibliographic Details
Main Authors: Barsi, S. (Author), Hunyady, L. (Author), Jakab, F. (Author), Kuczmog, A. (Author), Madai, M. (Author), Papp, H. (Author), Saez-Rodriguez, J. (Author), Szalai, B. (Author), Tóth, D.J (Author), Valdeolivas, A. (Author), Várnai, P. (Author)
Format: Article
Language:English
Published: Public Library of Science 2022
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