Peripartal treatment with low-dose sertraline accelerates mammary gland involution and has minimal effects on maternal and offspring bone

Peripartal treatment with low-dose sertraline accelerates mammary gland involution and has minimal effects on maternal and offspring bone

Women mobilize up to 10% of their bone mass during lactation to provide milk calcium. About 8%–13% of mothers use selective serotonin reuptake inhibitors (SSRI) to treat peripartum depression, but SSRIs independently decrease bone mass. Previously, peripartal use of the SSRI fluoxetine reduced mater...

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Bibliographic Details
Main Authors: Bell, A.M (Author), Charles, J.F (Author), Domingues, R.R (Author), Hernandez, L.L (Author), Hunt, E.R (Author), Manuel, R.S.J (Author), Sartori, L.C (Author), Scharpf, B.R (Author), Sheftel, C.M (Author), Vezina, C.M (Author), Wake, L.A (Author)
Format: Article
Language:English
Published: American Physiological Society 2022
Subjects:
adult
alexa fluor 594
animal experiment
animal model
animal tissue
Article
bicinchoninic acid assay
bone
bone densitometry
bone density
bone length
bone mass
bone metabolism
bone turnover
bone volume fraction
calcium blood level
calcium excretion
collagen type 1
controlled study
cytokeratin 8
deoxycholate sodium
duodenum
female
femur
fluoxetine
gene expression
histology
immunofluorescence
involution
kidney
lactation
lung alveolus
mammary gland
mammary gland involution
maternal age
milk production
mouse
nonhuman
nullipara
ossification
osteolysis
perinatal period
pregnancy
procollagen
progeny
protein expression
protein tyrosine phosphatase inhibitor
protein ZO1
reverse transcription polymerase chain reaction
ribonuclease inhibitor
RNA extraction
serotonin
serotonin uptake inhibitor
sertraline
SSRI
tight junction protein
uvomorulin
weaning
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