CYP2D6 gene resequencing in the Malagasy, a population at the crossroads between Asia and Africa: a pilot study

CYP2D6 gene resequencing in the Malagasy, a population at the crossroads between Asia and Africa: a pilot study

Background: Plasmodium vivax malaria is endemic in Madagascar, where populations have genetic inheritance from Southeast Asia and East Africa. Primaquine, a drug of choice for vivax malaria, is metabolized principally via CYP2D6. CYP2D6 variation was characterized by locus-specific gene sequencing a...

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Bibliographic Details
Main Authors: Chan, E.R (Author), Gaedigk, A. (Author), Mehlotra, R.K (Author), Pirani, K.A (Author), Ratsimbasoa, A.C (Author), Williams, S.M (Author), Zimmerman, P.A (Author)
Format: Article
Language:English
Published: Future Medicine Ltd. 2022
Subjects:
Africa
antimalarial agent
Antimalarials
Asia
CYP2D6
cytochrome P450 2D6
Cytochrome P-450 CYP2D6
genetics
human
Humans
Madagascar
malaria treatment
metabolism
next-generation sequencing
Pilot Projects
pilot study
Plasmodium vivax
primaquine
Primaquine
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