Effect of General Adiposity and Central Body Fat Distribution on the Circulating Metabolome: A Multicohort Nontargeted Metabolomics Observational and Mendelian Randomization Study

Effect of General Adiposity and Central Body Fat Distribution on the Circulating Metabolome: A Multicohort Nontargeted Metabolomics Observational and Mendelian Randomization Study

Obesity is associated with adverse health outcomes, but the metabolic effects have not yet been fully elucidated. We aimed to investigate the association between adiposity and circulating metabolites and to address causality with Mendelian randomization (MR). Metabolomics data were generated with no...

Full description

Bibliographic Details
Main Authors: Ahmad, S. (Author), Arnlov, J. (Author), Berne, C. (Author), Fall, T. (Author), Ganna, A. (Author), Hammar, U. (Author), Kennedy, B. (Author), Larsson, S.C (Author), Lind, L. (Author), Magnusson, P.K.E (Author), Riserus, U. (Author), Salihovic, S. (Author), Sundstrom, J. (Author)
Format: Article
Language:English
Published: American Diabetes Association Inc. 2022
Subjects:
abdominal obesity
Adiposity
adult
Adult
aged
Aged
Aged, 80 and over
blood
body fat distribution
Body Fat Distribution
body mass
Body Mass Index
clinical trial
cohort analysis
Cohort Studies
female
Female
Germany
human
Humans
male
Male
Mendelian randomization analysis
Mendelian Randomization Analysis
metabolism
metabolome
Metabolome
metabolomics
Metabolomics
middle aged
Middle Aged
multicenter study
obesity
Obesity, Abdominal
physiology
procedures
risk factor
Risk Factors
Sweden
United Kingdom
United States
very elderly
waist hip ratio
Waist-Hip Ratio
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items