Obesity Partially Mediates the Diabetogenic Effect of Lowering LDL Cholesterol

Obesity Partially Mediates the Diabetogenic Effect of Lowering LDL Cholesterol

OBJECTIVE LDL cholesterol (LDLc)-lowering drugs modestly increase body weight and type 2 diabetes risk, but the extent to which the diabetogenic effect of lowering LDLc is mediated through increased BMI is unknown. RESEARCH DESIGN AND METHODS We conducted summary-level univariable and multivariable...

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Main Authors: Ahmadizar, F. (Author), An, P. (Author), Brody, J.A (Author), Cai, J. (Author), Chasman, D.I (Author), Cuadrat, R.R.C (Author), Daghlas, I. (Author), Dupuis, J. (Author), Ellervik, C. (Author), Ericson, U. (Author), Feitosa, M.F (Author), Florez, J.C (Author), Floyd, J.S (Author), Franco, G. (Author), Ghanbari, M. (Author), Gill, D. (Author), Goodarzi, M.O (Author), Guo, X. (Author), Hindy, G. (Author), Ikram, M.A (Author), Isaksen, J.L (Author), Jager, S. (Author), Kalyani, R.R (Author), Kanters, J.K (Author), Kaplan, R.C (Author), Kavousi, M. (Author), Lange, L. (Author), Liu, C.-T (Author), Masana, L. (Author), Meigs, J.B (Author), Mercader, J.M (Author), Merino, J. (Author), Moon, J.-Y (Author), Olesen, M.S (Author), Orho-Melander, M. (Author), Porneala, B.C (Author), Province, M.A (Author), Psaty, B.M (Author), Qi, Q. (Author), Raffield, L.M (Author), Raghavan, S. (Author), Richardson, T.G (Author), Ridker, P.M (Author), Rotter, J.I (Author), Schulze, M.B (Author), Sitlani, C.M (Author), Smith, G.D (Author), Uitterlinden, A. (Author), Vaidya, D. (Author), Wu, P. (Author), Yanek, L.R (Author), Yao, J. (Author)
Format: Article
Language:English
Published: American Diabetes Association Inc. 2022
Subjects:
Cholesterol, LDL
complication
Diabetes Mellitus, Type 2
genetics
genome-wide association study
Genome-Wide Association Study
human
Humans
low density lipoprotein cholesterol
Mendelian randomization analysis
Mendelian Randomization Analysis
non insulin dependent diabetes mellitus
obesity
Obesity
risk factor
Risk Factors
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