Type 2 Diabetes Partitioned Polygenic Scores Associate With Disease Outcomes in 454,193 Individuals Across 13 Cohorts

Type 2 Diabetes Partitioned Polygenic Scores Associate With Disease Outcomes in 454,193 Individuals Across 13 Cohorts

OBJECTIVE: Type 2 diabetes (T2D) has heterogeneous patient clinical characteristics and outcomes. In previous work, we investigated the genetic basis of this heterogeneity by clustering 94 T2D genetic loci using their associations with 47 diabetes-related traits and identified five clusters, termed...

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Main Authors: Ahmadizar, F. (Author), Bielak, L.F (Author), Blokstra, A. (Author), Boerwinkle, E. (Author), Bottinger, E.P (Author), Chaker, L. (Author), Chen, Y. (Author), Chen, Y.-D.I (Author), Cole, J.B (Author), de Vries, P.S (Author), DiCorpo, D. (Author), Dupuis, J. (Author), Faquih, T. (Author), Florez, J.C (Author), Ghanbari, M. (Author), Goodarzi, M.O (Author), Gudmundsdottir, V. (Author), Gudnason, V. (Author), Guo, X. (Author), Hasbani, N.R (Author), Ibi, D. (Author), Ikram, M.A (Author), Jukema, J.W (Author), Kardia, S.L.R (Author), Kavousi, M. (Author), LeClair, J. (Author), Leonard, H.L (Author), Leong, A. (Author), Liu, C.-T (Author), Loos, R.J.F (Author), Manning, A.K (Author), Meigs, J.B (Author), Mercader, J.M (Author), Mook-Kanamori, D. (Author), Morrison, A.C (Author), Nadkarni, G.N (Author), Nalls, M.A (Author), Noordam, R. (Author), Pankow, J.S (Author), Picavet, H.S.J (Author), Preuss, M. (Author), Rotter, J.I (Author), Sarnowski, C. (Author), Sattar, N. (Author), Simonsick, E.M (Author), Smith, J.A (Author), Trompet, S. (Author), Udler, M.S (Author), Verschuren, W.M.M (Author), Vissink, P. (Author), Willems van Dijk, K. (Author), Yao, J. (Author), Zhao, W. (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
allele
Alleles
Child, Preschool
Cross-Sectional Studies
cross-sectional study
Diabetes Mellitus, Type 2
gene locus
Genetic Loci
genetic predisposition
Genetic Predisposition to Disease
genetics
genome-wide association study
Genome-Wide Association Study
human
Humans
non insulin dependent diabetes mellitus
obesity
Obesity
Polymorphism, Single Nucleotide
preschool child
single nucleotide polymorphism
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