Maternal Glycemic Dysregulation During Pregnancy and Neonatal Blood DNA Methylation: Meta-analyses of Epigenome-Wide Association Studies

Maternal Glycemic Dysregulation During Pregnancy and Neonatal Blood DNA Methylation: Meta-analyses of Epigenome-Wide Association Studies

OBJECTIVE: Maternal glycemic dysregulation during pregnancy increases the risk of adverse health outcomes in her offspring, a risk thought to be linearly related to maternal hyperglycemia. It is hypothesized that changes in offspring DNA methylation (DNAm) underline these associations. RESEARCH DESI...

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Main Authors: Alfano, R. (Author), Andrew, T. (Author), Annesi-Maesano, I. (Author), Binder, E. (Author), Bonnefond, A. (Author), Bouchard, L. (Author), Caiazzo, R. (Author), Canouil, M. (Author), Chan, J.K.Y (Author), Chong, Y.S (Author), Dabelea, D. (Author), Felix, J.F (Author), Froguel, P. (Author), Gaillard, R. (Author), Geurtsen, M.L (Author), Gluckman, P.D (Author), Heude, B. (Author), Hivert, M.-F (Author), Howe, C.G (Author), Hummel, S. (Author), Jaddoe, V.W.V (Author), Jarvelin, M.-R (Author), Juvinao-Quintero, D.L (Author), Kajantie, E. (Author), Karnani, N. (Author), Keikkala, E. (Author), Khamis, A. (Author), Küpers, L.K (Author), Lahti, J. (Author), Lim, I.Y (Author), Mustaniemi, S. (Author), Nawrot, T.S (Author), Ott, R. (Author), Pattou, F. (Author), Perron, P. (Author), Pesce, G. (Author), Plusquin, M. (Author), Raikkonen, K. (Author), Raverdy, V. (Author), Reimann, B. (Author), Ronkainen, J. (Author), Sebert, S. (Author), Starling, A.P (Author), Steegers-Theunissen, R.P.M (Author), Tan, K.H (Author), Tobi, E.W (Author), Tuhkanen, J. (Author), Tzala, E. (Author), Vääräsmäki, M. (Author), Winkler, C. (Author), Ziegler, A.-G (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
Diabetes Mellitus, Type 2
Diabetes, Gestational
DNA methylation
DNA Methylation
Epigenesis, Genetic
Epigenome
female
Female
Fetal Blood
fetus blood
genetic epigenesis
genetics
human
Humans
Infant, Newborn
metabolism
newborn
non insulin dependent diabetes mellitus
pregnancy
Pregnancy
pregnancy diabetes mellitus
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