The hexosamine pathway and coat complex II promote malignant adaptation to nutrient scarcity

The hexosamine pathway and coat complex II promote malignant adaptation to nutrient scarcity

The glucose-requiring hexosamine biosynthetic pathway (HBP), which produces UDP-N-acetylglucosamine for glycosylation reactions, promotes lung adenocarcinoma (LUAD) progression. However, lung tumor cells often reside in low-nutrient microenvironments, and whether the HBP is involved in the adaptatio...

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Bibliographic Details
Main Authors: Barthelaix, A. (Author), Brugière, S. (Author), Chaveroux, C. (Author), Couté, Y. (Author), Dragic, H. (Author), Duret, C. (Author), Ferraro-Peyret, C. (Author), Guitton, J. (Author), Hofman, P. (Author), Laprade, H. (Author), Le Goupil, S. (Author), Lebecque, S. (Author), Machon, C. (Author), Manié, S.N (Author), Martin, S. (Author), Renno, T. (Author), Rudewicz, J. (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
epidermal growth factor receptor
ErbB Receptors
genetics
glucose
Glucose
glycosylation
Glycosylation
hexosamine
Hexosamines
human
Humans
metabolism
Nutrients
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