AZD5153, a Bivalent BRD4 Inhibitor, Suppresses Hepatocarcinogenesis by Altering BRD4 Chromosomal Landscape and Modulating the Transcriptome of HCC Cells

AZD5153, a Bivalent BRD4 Inhibitor, Suppresses Hepatocarcinogenesis by Altering BRD4 Chromosomal Landscape and Modulating the Transcriptome of HCC Cells

BRD4, a chromatin modifier frequently upregulated in a variety of neoplasms including hepatocellular cancer (HCC), promotes cancer cell growth by activating oncogenes through its interaction with acetylated histone tails of nucleosomes. Here, we determined the anti-HCC efficacy of AZD5153, a potent...

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Bibliographic Details
Main Authors: Bai, X.-F (Author), Ghoshal, K. (Author), Koenig, A.B (Author), Kuo, J.C.-T (Author), Lee, R.J (Author), Li, D. (Author), Lin, C.-H (Author), Pan, A. (Author), Yan, P. (Author)
Format: Article
Language:English
Published: Frontiers Media S.A. 2022
Subjects:
AZD5153
BRD4 (bromodomain-containing protein 4)
ChIP-seq
HCC
nanoemulsion
NAPRT
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