Everolimus Alleviates Renal Allograft Interstitial Fibrosis by Inhibiting Epithelial-to-Mesenchymal Transition Not Only via Inducing Autophagy but Also via Stabilizing IκB-α

Chronic allograft dysfunction (CAD) is the major cause of late graft loss in long-term renal transplantation. In our previous study, we found that epithelial–mesenchymal transition (EMT) is a significant event in the progression of renal allograft tubulointerstitial fibrosis, and impaired autophagic...

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Bibliographic Details
Main Authors:	Chen, H. (Author), Fei, S. (Author), Gu, M. (Author), Gui, Z. (Author), Han, Z. (Author), Ju, X. (Author), Sun, L. (Author), Suo, C. (Author), Tan, R. (Author), Tao, J. (Author), Wang, Z. (Author), Zhang, H. (Author), Zheng, M. (Author)
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022
Subjects:	Akt signaling allotransplantation angiogenesis animal animal cell animal model animal tissue Animals Article autophagosome autophagy Autophagy autophagy (cellular) cell culture cell invasion cell migration Cells, Cultured chloroquine chronic renal graft dysfunction coimmunoprecipitation complication creatinine creatinine blood level down regulation drug effect drug mechanism electron microscopy EMT endothelial progenitor cell epithelial mesenchymal transition Epithelial-Mesenchymal Transition everolimus Everolimus fibronectin fibrosis Fibrosis Fischer 344 rat gene expression graft rejection Graft Rejection histone deacetylase 3 HK-2 [Human kidney] cell line I kappa B kinase alpha immunofluorescence immunoglobulin enhancer binding protein immunohistochemistry kidney Kidney kidney allograft kidney disease Kidney Diseases kidney fibrosis kidney function kidney transplantation Kidney Transplantation male mammalian target of rapamycin messenger RNA metabolism mitogen activated protein kinase 1 mitogen activated protein kinase 3 NF kB signaling NF-kappa B NF-KappaB Inhibitor alpha nonhuman procedures protein expression protein function protein kinase B protein phosphorylation rat Rats Rats, Inbred F344 real time polymerase chain reaction renal allograft interstitial fibrosis renal graft dysfunction RNA sequencing signal transduction Signal Transduction small interfering RNA transcription factor RelA transcriptome sequencing Transplantation, Homologous tumor necrosis factor upregulation urea nitrogen blood level uvomorulin Western blotting wound healing assay
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Everolimus Alleviates Renal Allograft Interstitial Fibrosis by Inhibiting Epithelial-to-Mesenchymal Transition Not Only via Inducing Autophagy but Also via Stabilizing IκB-α

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