Cleavage-Mediated Regulation of Myd88 Signaling by Inflammasome-Activated Caspase-1

Cleavage-Mediated Regulation of Myd88 Signaling by Inflammasome-Activated Caspase-1

Coordination among multiple signaling pathways ensures an appropriate immune response, where a signaling pathway may impair or augment another signaling pathway. Here, we report a negative feedback regulation of signaling through the key innate immune mediator MyD88 by inflammasome-activated caspase...

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Bibliographic Details
Main Authors: Avbelj, M. (Author), Gole, B. (Author), Hafner-Bratkovič, I. (Author), Jerala, R. (Author), Lainšček, D. (Author), Manček-Keber, M. (Author), Panter, G. (Author), Peternelj, T.T (Author), Potočnik, U. (Author), Treon, S.P (Author)
Format: Article
Language:English
Published: Frontiers Media S.A. 2022
Subjects:
animal
animal experiment
animal model
Animals
Article
cancer growth
cancer inhibition
Casp1 protein, mouse
Caspase 1
caspase 3
caspase-1
cell viability
chromatin immunoprecipitation
controlled study
cryopyrin
cytokine production
cytokine release
enzyme activation
Enzyme Activation
enzyme linked immunosorbent assay
gene overexpression
genetic association
genetic transfection
genetics
HEK293 cell line
HEK293 Cells
human
Humans
immune response
Immunity, Innate
immunology
inflammasome
inflammasomes
Inflammasomes
inflammation
innate immunity
interleukin 1 receptor
interleukin 18
interleukin 1beta
interleukin 1beta converting enzyme
interleukin 6
knockout mouse
lactate dehydrogenase
lipopolysaccharide
luciferase assay
macrophage
Mice
Mice, Knockout
mouse
mutagenesis
Myd88
MYD88 protein, human
Myd88 protein, mouse
myeloid differentiation factor 88
Myeloid Differentiation Factor 88
negative feedback
nonhuman
pathogen associated molecular pattern
phenazine methosulfate
protein expression
protein phosphorylation
pyroptosis
regulation
sequence alignment
signal transduction
Signal Transduction
site directed mutagenesis
T lymphocyte activation
thioglycolic acid
THP-1 cell line
THP-1 Cells
TLR signaling
toll like receptor
toll like receptor 2
toll like receptor 4
tumor necrosis factor
ubiquitination
urate
Western blotting
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