Immune Regulatory 1 Cells: A Novel and Potent Subset of Human T Regulatory Cells

A subset of T regulatory cells (Tregs), identified by TIRC7 (T cell immune response cDNA 7) expression is designated as Immune Regulatory 1 Cells (IR1 cells). TIRC7 is an immune checkpoint inhibitor, co-localized with the T- cell receptor, HLA-DR and CTLA-4 during T-cell activation, which delivers r...

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Bibliographic Details
Main Authors:	Appis, M. (Author), Beato, F. (Author), Goodyear, M. (Author), Haas, J.F (Author), Hammerich, L. (Author), Krause, N. (Author), Kuehl, A. (Author), Mengwasser, J. (Author), Milford, E.L (Author), Müller, T. (Author), Phithak, E. (Author), Pratschke, J. (Author), Sauer, I. (Author), Tacke, F. (Author), Utku, N. (Author), Vogel, A. (Author)
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022
Subjects:	adult Article autoimmunity binding affinity C-C motif chemokine receptor 7 CD3 antigen CD39 antigen CD4 antigen CD4+ T lymphocyte CD8+ T lymphocyte cell membrane potential cell proliferation clinical article controlled study COS7 cell line cytosol aminopeptidase enzyme female flow cytometry fluorescence activated cell sorting gene expression glycoprotein A repetitions predominant HLA DR antigen homeostasis human human cell human tissue immune regulatory Cell 1 immune response interleukin 10 interleukin 2 interleukin 2 receptor alpha interleukin 5 receptor alpha IR1 cells L selectin major histocompatibility antigen class 2 male membrane protein mixed lymphocyte reaction normal human peripheral blood mononuclear cell programmed death 1 receptor protein expression quality control regulatory T lymphocyte T cell immune response cDNA 7 T lymphocyte activation T regulatory cells TIRC7 transcription factor FOXP3 unclassified drug
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Immune Regulatory 1 Cells: A Novel and Potent Subset of Human T Regulatory Cells

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