Single-Cell Multiomics Reveals Clonal T-Cell Expansions and Exhaustion in Blastic Plasmacytoid Dendritic Cell Neoplasm

Single-Cell Multiomics Reveals Clonal T-Cell Expansions and Exhaustion in Blastic Plasmacytoid Dendritic Cell Neoplasm

The immune system represents a major barrier to cancer progression, driving the evolution of immunoregulatory interactions between malignant cells and T-cells in the tumor environment. Blastic plasmacytoid dendritic cell neoplasm (BPDCN), a rare acute leukemia with plasmacytoid dendritic cell (pDC)...

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Bibliographic Details
Main Authors: Ainciburu, M. (Author), Aranki, S.F (Author), Couturier, C.P (Author), DePasquale, E.A.K (Author), Good, J. (Author), Griffin, G.K (Author), Lane, A.A (Author), Mallidi, H.R (Author), Noel, J. (Author), Shalek, A.K (Author), Ssozi, D. (Author), van Galen, P. (Author), Villanueva, M.A (Author)
Format: Article
Language:English
Published: Frontiers Media S.A. 2022
Subjects:
bioinformatics
BPDCN
cancer
multiomics
single-cell
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