Cohesin-Mediated Chromatin Interactions and Autoimmunity

Cohesin-Mediated Chromatin Interactions and Autoimmunity

Proper physiological functioning of any cell type requires ordered chromatin organization. In this context, cohesin complex performs important functions preventing premature separation of sister chromatids after DNA replication. In partnership with CCCTC-binding factor, it ensures insulator activity...

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Bibliographic Details
Main Authors: Andersson, K.M.E (Author), Bokarewa, M.I (Author), Chandrasekaran, V. (Author), Erlandsson, M.C (Author), Garcia-Bonete, M.-J (Author), Jensen, M. (Author), Katona, G. (Author), Malmhäll-Bah, E. (Author), Oparina, N. (Author), Silfverswärd, S.T (Author), Wasén, C. (Author)
Format: Article
Language:English
Published: Frontiers Media S.A. 2022
Subjects:
adipogenesis
autoimmune disease
autoimmunity
C reactive protein
canonical analysis
CCCTC-binding factor
CDCA5
chromatin
cohesin
CTCF
DNA replication
gamma interferon
gene frequency
gene locus
gene mutation
gene silencing
genetic association
genetic transcription
genome analysis
genome organization
genome-wide association study
hematologic malignancy
hematopoiesis
HLA B27 antigen
homozygosity
immune signaling
immunocompetent cell
immunoglobulin enhancer binding protein
inflammation
interleukin 2
interleukin 6
knockout gene
lymphocyte antigen receptor
major histocompatibility complex
MAU2
monogenic disorder
nonhuman
PDS5B
peptides and proteins
PLK1
protein protein interaction
regulatory T lymphocyte
Review
SGO1
short hairpin RNA
single nucleotide polymorphism
sister chromatid
small interfering RNA
SMC1B
SMC3
somatic mutation
STAG1
Th1 cell
Th2 cell
transcription factor CTCF
transcription factor FOXP3
transcription factor GATA 1
transcription factor GATA 2
transcription factor GATA 3
type II interferon signaling
unclassified drug
zinc finger protein
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