Synergistic Anti-Tumor Effect of Combining Selective CDK7 and BRD4 Inhibition in Neuroblastoma

Synergistic Anti-Tumor Effect of Combining Selective CDK7 and BRD4 Inhibition in Neuroblastoma

Purpose: Cyclin-dependent kinases (CDKs) that have critical roles in RNA polymerase II (Pol II)-mediated gene transcription are emerging as therapeutic targets in cancer. We have previously shown that THZ1, a covalent inhibitor of CDKs 7/12/13, leads to cytotoxicity in MYCN-amplified neuroblastoma t...

Full description

Bibliographic Details
Main Authors: Abraham, B.J (Author), Das, S. (Author), Gao, Y. (Author), George, R.E (Author), Gray, N.S (Author), Gustafson, C. (Author), Krajewska, M. (Author), Kwiatkowski, N. (Author), Nasholm, N. (Author), Volegova, M. (Author), Zhang, T. (Author)
Format: Article
Language:English
Published: Frontiers Media S.A. 2022
Subjects:
BRD4
CDK7
MYCN amplification
neuroblastoma
resistance
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items