Synergistic Anti-Tumor Effect of Combining Selective CDK7 and BRD4 Inhibition in Neuroblastoma
Purpose: Cyclin-dependent kinases (CDKs) that have critical roles in RNA polymerase II (Pol II)-mediated gene transcription are emerging as therapeutic targets in cancer. We have previously shown that THZ1, a covalent inhibitor of CDKs 7/12/13, leads to cytotoxicity in MYCN-amplified neuroblastoma t...
Main Authors: | Abraham, B.J (Author), Das, S. (Author), Gao, Y. (Author), George, R.E (Author), Gray, N.S (Author), Gustafson, C. (Author), Krajewska, M. (Author), Kwiatkowski, N. (Author), Nasholm, N. (Author), Volegova, M. (Author), Zhang, T. (Author) |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2022
|
Subjects: | |
Online Access: | View Fulltext in Publisher |
Similar Items
-
MYCN Amplification Is Associated with Reduced Expression of Genes Encoding γ-Secretase Complex and NOTCH Signaling Components in Neuroblastoma
by: Agarwal, P., et al.
Published: (2023) -
PROTAC Bromodomain Inhibitor ARV-825 Displays Anti-Tumor Activity in Neuroblastoma by Repressing Expression of MYCN or c-Myc
by: Zhiheng Li, et al.
Published: (2020-11-01) -
Implementation of the plasma MYCN/NAGK ratio to detect MYCN amplification in patients with neuroblastoma
by: Yan Su, et al.
Published: (2020-11-01) -
Concurrent targeting of MAP3K3 and BRD4 by miR-3140-3p overcomes acquired resistance to BET inhibitors in neuroblastoma cells
by: Chang Liu, et al.
Published: (2021-09-01) -
Unfavorable Outcome of Neuroblastoma in Patients With 2p Gain
by: Katarzyna Szewczyk, et al.
Published: (2019-10-01)