Transcriptomic Regulation of Muscle Mitochondria and Calcium Signaling by Insulin/IGF-1 Receptors Depends on FoxO Transcription Factors

Transcriptomic Regulation of Muscle Mitochondria and Calcium Signaling by Insulin/IGF-1 Receptors Depends on FoxO Transcription Factors

Insulin and IGF-1, acting through the insulin receptor (IR) and IGF-1 receptor (IGF1R), maintain muscle mass and mitochondrial function, at least part of which occurs via their action to regulate gene expression. Here, we show that while muscle-specific deletion of IR or IGF1R individually results i...

Full description

Bibliographic Details
Main Authors: Bhardwaj, G. (Author), Dreyfuss, J.M (Author), Kahn, C.R (Author), Klaus, K. (Author), Nair, K.S (Author), O’Neill, B.T (Author), Pan, H. (Author), Penniman, C.M (Author), Weatherford, E.T (Author)
Format: Article
Language:English
Published: Frontiers Media S.A. 2022
Subjects:
calcium signaling
diabetes
FoxO transcription factors
insulin/IGF-1 receptors
mitochondrial dysfunction
muscle transcription
RNA sequencing
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items