Neurodegenerative Disease Treatment Drug PBT2 Breaks Intrinsic Polymyxin Resistance in Gram‐Positive Bacteria

Gram‐positive bacteria do not produce lipopolysaccharide as a cell wall component. As such, the polymyxin class of antibiotics, which exert bactericidal activity against Gram‐negative pathogens, are ineffective against Gram‐positive bacteria. The safe‐for‐human‐use hydroxyquino-line analog ionophore...

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Bibliographic Details
Main Authors:	Bohlmann, L. (Author), Brouwer, S. (Author), Cork, A.J (Author), Davies, M.R (Author), De Oliveira, D.M.P (Author), El‐deeb, I.M (Author), Harbison‐price, N. (Author), Hayes, A.J (Author), Jones, T.R (Author), Keller, B. (Author), Keller, N. (Author), Li, G. (Author), McDevitt, C.A (Author), McEwan, A.G (Author), Ong, C.-L.Y (Author), Paterson, D.L (Author), Turner, A.G (Author), von Itzstein, M. (Author), Walker, M.J (Author)
Format:	Article
Language:	English
Published:	MDPI 2022
Subjects:	ampicillin animal experiment animal model antibacterial activity antibiotic agent antibiotic resistance antibiotic sensitivity antimicrobial resistance Article bacterial gene bacterial growth bacterial strain bactericidal activity bloodstream infection broth dilution ciprofloxacin cohort analysis colistin colistin resistance comparative study controlled study degenerative disease disk diffusion DNA extraction Enterococcus faecium Escherichia coli fusidic acid gene mutation Gram positive bacterium Gram positive infection Gram‐positive bacteria homeostasis human inductively coupled plasma atomic emission spectrometry ionophores lipopolysaccharide metal ion methicillin resistant Staphylococcus aureus minimum inhibitory concentration mutagenesis nonhuman oxidative stress PBT2 polymyxin polymyxin B polymyxin resistance polymyxins real time polymerase chain reaction RNA isolation scanning electron microscopy single nucleotide polymorphism skin infection Staphylococcus aureus Staphylococcus epidermidis Streptococcus pyogenes vancomycin vancomycin resistant Enterococcus whole genome sequencing wound infection zinc
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Neurodegenerative Disease Treatment Drug PBT2 Breaks Intrinsic Polymyxin Resistance in Gram‐Positive Bacteria

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