TLR4 Signaling and Heme Oxygenase‐1/Carbon Monoxide Pathway Crosstalk Induces Resiliency of Myeloma Plasma Cells to Bortezomib Treatment

TLR4 Signaling and Heme Oxygenase‐1/Carbon Monoxide Pathway Crosstalk Induces Resiliency of Myeloma Plasma Cells to Bortezomib Treatment

Relapse in multiple myeloma (MM) decreases therapy efficiency through unclear mechanisms of chemoresistance. Since our group previously demonstrated that heme oxygenase‐1 (HO‐1) and Toll‐like receptor 4 (TLR4) are two signaling pathways protecting MM cells from the proteasome inhibitor bortezomib (B...

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Main Authors: Di Raimondo, F. (Author), Di Rosa, M. (Author), Foresti, R. (Author), Giallongo, C. (Author), Giallongo, S. (Author), Longhitano, L. (Author), Motterlini, R. (Author), Musumeci, G. (Author), Palumbo, G.A (Author), Parrinello, N.L (Author), Puglisi, F. (Author), Romano, A. (Author), Scandura, G. (Author), Tibullo, D. (Author), Volti, G.L (Author), Zuppelli, T. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
bortezomib
mitochondria
multiple myeloma
TLR4/HO‐1 crosstalk
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