Distribution of Charged Residues Affects the Average Size and Shape of Intrinsically Disordered Proteins

Distribution of Charged Residues Affects the Average Size and Shape of Intrinsically Disordered Proteins

Intrinsically disordered proteins (IDPs) are ensembles of interconverting conformers whose conformational properties are governed by several physico-chemical factors, including their amino acid composition and the arrangement of oppositely charged residues within the primary structure. In this work,...

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Bibliographic Details
Main Authors: Barbiroli, A. (Author), Bianchi, G. (Author), Brocca, S. (Author), Grandori, R. (Author), Longhi, S. (Author), Mangiagalli, M. (Author), Santambrogio, C. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
agarose
alcohol dehydrogenase
amino acid
amino acid composition
ammonium acetate
arginine
Article
average shape of conformational ensembles
bioinformatics
bovine serum albumin
buffer
carbonate dehydratase
charge clustering
charged-residue patterning
circular dichroism
conforma-tional compactness
cytochrome c
dextran
electrospray
ellipsoid model
erythrocyte
Escherichia coli
ferritin
formic acid
Hendra virus
histidine
hydrodynamic radius
immobilized metal affinity chromatography
intrinsically disordered protein
ionic strength
lysine
mass spectrometry
Measles virus
molecular cloning
neurofilament protein
nitrilotriacetate nickel
nonhuman
ovalbumin
phosphate buffered saline
plasmid DNA
polarimetry
polyelectrolytes
proline
proline content
resin
sequence analysis
size exclusion chromatography
sodium chloride
sodium dihydrogen phosphate
solvent-accessible surface area
uracil
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