Aerobic exercise training and in vivo akt activation counteract cancer cachexia by inducing a hypertrophic profile through eif-2α modulation

Aerobic exercise training and in vivo akt activation counteract cancer cachexia by inducing a hypertrophic profile through eif-2α modulation

Cancer cachexia is a multifactorial and devastating syndrome characterized by severe skeletal muscle mass loss and dysfunction. As cachexia still has neither a cure nor an effective treatment, better understanding of skeletal muscle plasticity in the context of cancer is of great importance. Althoug...

Full description

Bibliographic Details
Main Authors: Borges, G.S (Author), Bowen, T.S (Author), Brum, P.C (Author), de Almeida, N.R (Author), de Souza, L. (Author), Demasi, M. (Author), Miyabara, E.H (Author), Paixão, A.O (Author), Pereira, M.G (Author), Tobias, G.C (Author), Voltarelli, V.A (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
Akt/mTORC1 signaling
Akt-induced hypertrophy
Cancer cachexia
EIF-2α
Physical exercise
Skeletal muscle plasticity
Translation initiation
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items