Platelet-Derived PDGFB Promotes Recruitment of Cancer-Associated Fibroblasts, Deposition of Extracellular Matrix and Tgfβ Signaling in the Tumor Microenvironment

Platelet-Derived PDGFB Promotes Recruitment of Cancer-Associated Fibroblasts, Deposition of Extracellular Matrix and Tgfβ Signaling in the Tumor Microenvironment

Platelets constitute a major reservoir of platelet-derived growth factor B (PDGFB) and are continuously activated in the tumor microenvironment, exposing tumors to the plethora of growth factors contained in platelet granules. To address the specific role of platelet-derived PDGFB in the tumor micro...

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Bibliographic Details
Main Authors: Cedervall, J. (Author), Hamidi, A. (Author), Hellman, L. (Author), Herre, M. (Author), Kamali-Moghaddam, M. (Author), Manouchehri Doulabi, E. (Author), Miao, Z. (Author), Olsson, A.-K (Author), Qiao, Q. (Author), Zhang, Y. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
extracellular matrix
PDGFB
platelets
proximity extension assay (PEA)
TGFβ
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