A next generation sequencing-based protocol for screening of variants of concern in autism spectrum disorder

Autism spectrum disorder (ASD) is a neurodevelopmental disorder with strong genetic influences. There is an increasing demand for ASD genetic testing beyond the traditionally recom-mended microarray and syndromic autism testing; however, the current whole genome sequencing (WGS) and whole exome sequ...

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Bibliographic Details
Main Authors:	Budjan, C. (Author), Fong, M. (Author), Huang, J. (Author), Jeong, M.-S (Author), Kong, X.-J (Author), Liu, J. (Author), Liu, K. (Author), Sherman, H.T (Author), Tian, R. (Author), Zhuang, P. (Author)
Format:	Article
Language:	English
Published:	MDPI 2022
Subjects:	adolescent Adolescent adult amino acid transporter Article autism Autism Spectrum Disorder Autism Spectrum Disorder (ASD) bioinformatics Bioinformatics pipeline blood sampling child Child Child, Preschool clinical article cohort analysis Cohort Studies comorbidity Comorbidity DNA extraction female Female gene expression gene frequency gene mutation genetic analysis genetic predisposition Genetic Predisposition to Disease Genetic report genetic screening genetic susceptibility Genetic Testing genetics genome analysis high throughput screening high throughput sequencing High-Throughput Nucleotide Sequencing human Humans male Male microRNA Molecular diagnostics mutation Mutation nervous system development Pathogenic variants pathophysiology pipeline Precision medicine preschool child real time polymerase chain reaction reproducibility Reproducibility of Results Sanger sequencing signal transduction single nucleotide polymorphism transfer RNA Trios variant of concern whole exome sequencing Whole exome sequencing Whole Exome Sequencing whole genome sequencing Whole genome sequencing young adult Young Adult
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A next generation sequencing-based protocol for screening of variants of concern in autism spectrum disorder

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