Glucocorticoid-Induced Leucine Zipper Alleviates Lung Inflammation and Enhances Bacterial Clearance During Pneumococcal Pneumonia

Glucocorticoid-Induced Leucine Zipper Alleviates Lung Inflammation and Enhances Bacterial Clearance During Pneumococcal Pneumonia

Pneumonia is a leading cause of morbidity and mortality. While inflammation is a host protective response that ensures bacterial clearance, a finely regulated response is necessary to prevent bystander tissue damage. Glucocorticoid (GC)-induced leucine zipper (GILZ) is a GC-induced protein with anti...

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Bibliographic Details
Main Authors: Bruscoli, S. (Author), Cardoso, C. (Author), Carvalho, A.F.S (Author), de Oliveira, L.C (Author), Grossi, L.C (Author), Machado, M.G (Author), Morand, E.F (Author), Queiroz-Junior, C.M (Author), Riccardi, C. (Author), Sousa, L.P (Author), Souza, G.V.S (Author), Souza, J.A.M (Author), Tavares, L.P (Author), Teixeira, M.M (Author), Vago, J.P (Author), Zaidan, I. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
Acute lung injury
animal experiment
animal model
antiinflammatory activity
Article
bacterial clearance
cell infiltration
computer assisted tomography
disease severity
disk diffusion
efferocytosis
fusion protein
gamma interferon
glucocorticoid
high mobility group B1 protein
Inflammation resolution
interleukin 17
interleukin 6
leucine zipper protein
leukocyte count
lipopolysaccharide
lung function
lung injury
minimum inhibitory concentration
mouse
myeloperoxidase
neutrophil chemotaxis
neutrophilic inflammation
nonhuman
phenotype
procalcitonin
Proresolving mediators
protein function
RANTES
Streptococcus pneumonia
Streptococcus pneumoniae
toll like receptor 2
tumor necrosis factor
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