Peripheral Inflammatory Cytokine Signature Mirrors Motor Deficits in Mucolipidosis IV

Peripheral Inflammatory Cytokine Signature Mirrors Motor Deficits in Mucolipidosis IV

Background: Mucolipidosis IV (MLIV) is an autosomal recessive pediatric disease that leads to motor and cognitive deficits and loss of vision. It is caused by a loss of function of the lysosomal channel transient receptor potential mucolipin-1 and is associated with an early pro-inflammatory brain p...

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Bibliographic Details
Main Authors: Furness, A. (Author), Grishchuk, Y. (Author), Misko, A.L (Author), Sankar, S.B (Author), Weinstock, L.D (Author), Wood, L.B (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
animal
animal experiment
animal model
Animals
Article
biological marker
Biomarkers
Blood
blood sampling
Chemokine CXCL10
controlled study
cross validation
cytokine
Cytokines
disease exacerbation
disease model
Disease Models, Animal
female
gamma interferon
gamma interferon inducible protein 10
genetics
genotype
human
Humans
interferon
Interferons
interleukin 1
Lysosomal storage disorder
lysosome storage disease
male
metabolism
Mice
Motor function
motor performance
mouse
Mucolipidoses
mucolipidosis
Mucolipidosis
mucolipidosis type 4
nonhuman
pathology
phenotype
Plasma
transient receptor potential channel
Transient Receptor Potential Channels
tumor necrosis factor
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