Spatial and Genomic Correlates of HIV-1 Integration Site Targeting

Spatial and Genomic Correlates of HIV-1 Integration Site Targeting

HIV-1 integrase and capsid proteins interact with host proteins to direct preintegration complexes to active transcription units within gene-dense regions of chromosomes for viral DNA integration. Analyses of spatially-derived genomic DNA coordinates, such as nuclear speckle-asso-ciated domains, lam...

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Bibliographic Details
Main Authors: Bedwell, G.J (Author), Engelman, A.N (Author), Singh, P.K (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
acquired immune deficiency syndrome
Article
binding kinetics
capsid protein
CD4+ T lymphocyte
chemokine receptor CCR5
chromatin
chromatin immunoprecipitation
chromosome 20
cleavage and polyadenylation specificity factor
CPSF6
equine infectious anemia
gene expression
genetic marker
genetic transcription
genomic DNA
HIV/AIDS
host factor
Human immunodeficiency virus 1
Human immunodeficiency virus infection
immunoprecipitation
integrase
intron
Lamina-associated domains
LEDGF/p75
lens epithelium derived growth factor
molecular dynamics
nuclear speckle
Nuclear speckles
retroposon
Retroviral integration
RNA polymerase II
Speckle-associated domains
transcription factor
virus capsid
virus DNA
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