APOB CRISPR-Cas9 Engineering in Hypobetalipoproteinemia: A Promising Tool for Functional Studies of Novel Variants

APOB CRISPR-Cas9 Engineering in Hypobetalipoproteinemia: A Promising Tool for Functional Studies of Novel Variants

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Hypobetalipoproteinemia is characterized by LDL-cholesterol and apolipoprotein B (apoB) plasma levels below the fifth percentile for age and sex. Familial hypobetalipoproteinemia (FHBL) is mostly caused by premature termination codons in the APOB gene, a condition associated with fatty liver and ste...

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Main Authors: Caillaud, A. (Author), Cariou, B. (Author), Chatelain, C. (Author), Di Filippo, M. (Author), Dijk, W. (Author), Durand, C. (Author), Gossez, M. (Author), Janin, A. (Author), Lindenbaum, P. (Author), Marmontel, O. (Author), Moulin, P. (Author), Nony, S. (Author), Rieusset, J. (Author), Rimbert, A. (Author), Vanhoye, X. (Author), Venet, F. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
apolipoprotein B
cholesterol
functionality
genome editing
primary hypobetalipoproteinemia
secretion
variants of uncertain significance
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