Exclusion of NUMB Exon12 Controls Cancer Cell Migration through Regulation of Notch1-SMAD3 Crosstalk

Exclusion of NUMB Exon12 Controls Cancer Cell Migration through Regulation of Notch1-SMAD3 Crosstalk

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NUMB is an endocytic adaptor protein that contains four isoforms (p65, p66, p71 and p72) due to alternative splicing regulation. Here, we show that NUMB exon12 (E12)-skipping isoforms p65/p66 promote epithelial to mesenchymal transition (EMT) and cancer cell migration in vitro, and facilitate cancer...

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Bibliographic Details
Main Authors: Chen, R. (Author), Feng, Y. (Author), Meng, K. (Author), Peng, Q. (Author), Sha, R. (Author), Wang, Z. (Author), Xie, Z. (Author), You, X. (Author), Yuan, N. (Author), Zhan, Z. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
cell migration
isoforms
Notch1
NUMB
SMAD3
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