Transgenerational Transcriptomic and DNA Methylome Profiling of Mouse Fetal Testicular Germline and Somatic Cells after Exposure of Pregnant Mothers to Tributyltin, a Potent Obesogen

Transgenerational Transcriptomic and DNA Methylome Profiling of Mouse Fetal Testicular Germline and Somatic Cells after Exposure of Pregnant Mothers to Tributyltin, a Potent Obesogen

Obesogens such as tributyltin (TBT) are xenobiotic compounds that promote obesity, in part by distorting the normal balance of lipid metabolism. The obesogenic effects of TBT can be observed in directly exposed (F1 and F2 generations) and also subsequent generations (F3 and beyond) that were never e...

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Bibliographic Details
Main Authors: Blumberg, B. (Author), Odajima, J. (Author), Shioda, K. (Author), Shioda, T. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
animal cell
animal experiment
animal model
Article
body composition
cell differentiation
controlled study
CpG island
diet-induced obesity
Diet-induced obesity
dimethyl sulfoxide
DNA methylation
endoplasmic reticulum stress
fat mass
female
gene silencing
lipid diet
lipid metabolism
male
MBD-seq
methylome
mouse
nonhuman
nuclear magnetic resonance
Obesity
Obesogen
primordial germ cell
Primordial germ cells
principal component analysis
protein expression
protein fingerprinting
quality control
RNA sequencing
RNA-seq
Transgenerational
tributyltin
Tributyltin
upregulation
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