Development of Bicyclo[3.1.0]hexane-Based A3 Receptor Ligands: Closing the Gaps in the Structure–Affinity Relationships

Development of Bicyclo[3.1.0]hexane-Based A3 Receptor Ligands: Closing the Gaps in the Structure–Affinity Relationships

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The adenosine A3 receptor is a promising target for treating and diagnosing inflammation and cancer. In this paper, a series of bicyclo[3.1.0]hexane-based nucleosides was synthesized and evaluated for their P1 receptor affinities in radioligand binding studies. The study focused on modifications at...

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Bibliographic Details
Main Authors: Daniliuc, C.G (Author), Heitman, L.H (Author), Isaak, A. (Author), Jacobson, K.A (Author), Junker, A. (Author), Kock, M. (Author), Lemmerhirt, J.P (Author), Liu, R. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
A3 receptors
Adenosine receptors
bicyclo[3.1.0]hexane
methanocarba
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