The Root Extract of Peucedanum praeruptorum Dunn Exerts Anticancer Effects in Human Non-Small-Cell Lung Cancer Cells with Different EGFR Mutation Statuses by Suppressing MET Activity

The Root Extract of Peucedanum praeruptorum Dunn Exerts Anticancer Effects in Human Non-Small-Cell Lung Cancer Cells with Different EGFR Mutation Statuses by Suppressing MET Activity

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The aim of this study was to investigate the anticancer effects of the root extract of Peucedanum praeruptorum Dunn (EPP) in human non-small-cell lung cancer (NSCLC) cells and explore the mechanisms of action. We used four types of human lung cancer cell lines, including H1299 (epidermal gr...

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Bibliographic Details
Main Authors: Jeong, J.-H (Author), Park, H.-J (Author), Park, S.-H (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
apoptosis
Carcinoma, Non-Small-Cell Lung
Cell Line, Tumor
cell proliferation
Cell Proliferation
drug resistance
Drug Resistance, Neoplasm
EGFR mutation
EGFR protein, human
EGFR TKI resistance
epidermal growth factor receptor
ErbB Receptors
genetics
human
Humans
Lung Neoplasms
lung tumor
MET
metabolism
mutation
Mutation
non small cell lung cancer
non-small-cell lung cancer
Peucedanum praeruptorum Dunn
plant extract
Plant Extracts
protein kinase inhibitor
Protein Kinase Inhibitors
tumor cell line
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