Human Cytomegalovirus Nuclear Egress Complex Subunit, UL53, Associates with Capsids and Myosin Va, but Is Not Important for Capsid Localization towards the Nuclear Periphery

Human Cytomegalovirus Nuclear Egress Complex Subunit, UL53, Associates with Capsids and Myosin Va, but Is Not Important for Capsid Localization towards the Nuclear Periphery

After herpesviruses encapsidate their genomes in replication compartments (RCs) within the nuclear interior, capsids migrate to the inner nuclear membrane (INM) for nuclear egress. For human cytomegalovirus (HCMV), capsid migration depends at least in part on nuclear myosin Va. It has been reported...

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Bibliographic Details
Main Authors: Coen, D.M (Author), Coughlin, M. (Author), Ericsson, M. (Author), Fernandez, R. (Author), Lawler, J.L (Author), Pesola, J.M (Author), Sharma, M. (Author), Wilkie, A.R (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
Article
Capsid migration
capsid protein
cell culture
chemoluminescence
coimmunoprecipitation
Complementing cells
confocal laser scanning microscopy
electron microscopy
fluorescence microscopy
genetic transfection
human
human cell
Human cytomegalovirus
image analysis
immunoblotting
immunofluorescence assay
immunoprecipitation
liquid chromatography-mass spectrometry
Major capsid protein
mass spectrometry
Mass spectrometry
myosin Va
Myosin Va
nonhuman
nuclear egress complex
Null mutants
protein expression
proteomics
transmission electron microscopy
UL50
UL53
unclassified drug
viral protein
virus capsid
Virus genetics
virus purification
virus replication
Western blotting
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