Fatal Neurodissemination and SARS-CoV-2 Tropism in K18-hACE2 Mice Is Only Partially Dependent on hACE2 Expression

Fatal Neurodissemination and SARS-CoV-2 Tropism in K18-hACE2 Mice Is Only Partially Dependent on hACE2 Expression

Animal models recapitulating COVID-19 are critical to enhance our understanding of SARS-CoV-2 pathogenesis. Intranasally inoculated transgenic mice expressing human angiotensinconverting enzyme 2 under the cytokeratin 18 promoter (K18-hACE2) represent a lethal model of SARS-CoV-2 infection. We evalu...

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Bibliographic Details
Main Authors: Balasuriya, U.B.R (Author), Bosmann, M. (Author), Carossino, M. (Author), Crossland, N.A (Author), Douam, F. (Author), Ericsson, M. (Author), Francis, K.P (Author), Gertje, H.P (Author), Grosz, K.A (Author), Huber, B.R (Author), Kenney, D. (Author), Kirkland, T.A (Author), Klose, A.D (Author), Kurnick, S.A (Author), Montanaro, P. (Author), O’connell, A.K (Author), Paragas, N. (Author), Saeed, M. (Author), Subramaniam, S. (Author), Tseng, A.E (Author), Walker, J.R (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
animal
Animals
Comparative pathology
COVID-19
cytokeratin 18
dipeptidyl carboxypeptidase
gamma-Globulins
genetics
human
Humans
immunoglobulin
Immunohistochemistry
In situ hybridization
In vivo imaging
K-18 conjugate
Keratin-18
melphalan
Melphalan
metabolism
Mice
Mice, Transgenic
mouse
Peptidyl-Dipeptidase A
SARS-CoV-2
transgenic mouse
Translational animal model
Transmission electron microscopy
tropism
Tropism
Viral pathogenesis
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