Atorvastatin reduces IOP in ocular hypertension in vivo and suppresses ECM in trabecular meshwork perhaps via FGD4

Atorvastatin reduces IOP in ocular hypertension in vivo and suppresses ECM in trabecular meshwork perhaps via FGD4

To explore the role of atorvastatin in regulating intraocular pressure (IOP) in glaucoma in vivo, and to investigate its related molecular pathway in vitro, an ocular hypertension model was generated by intravitreal injection of an adenoviral vector encoding transforming growth factor (TGF)‑β2 in th...

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Bibliographic Details
Main Authors: Chen, Y.-Y (Author), Cong, L. (Author), Liu, W.-T (Author), Song, X.-Y (Author), Zhang, J.-L (Author), Zhang, Y. (Author), Zhang, Y.-Y (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
atorvastatin
extracellular matrix
FGD4
ocular hypertension mouse model
primary human trabecular meshwork cells
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