Ricolinostat enhances adavosertib-induced mitotic catastrophe in TP53-mutated head and neck squamous cell carcinoma cells

Ricolinostat enhances adavosertib-induced mitotic catastrophe in TP53-mutated head and neck squamous cell carcinoma cells

TP53mutation is one of the most frequent gene muta- tions in head and neck squamous cell carcinoma (HNSCC) and could be a potential therapeutic target. Recently, the WEE1 G2 checkpoint kinase (WEE1) inhibitor adavosertib (Adv) has attracted attention because of its selective cytotoxicity against TP5...

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Bibliographic Details
Main Authors: Hiramoto, M. (Author), Kazama, H. (Author), Kikuchi, H. (Author), Miyake, K. (Author), Miyazawa, K. (Author), Takano, N. (Author), Tsukahara, K. (Author)
Format: Article
Language:English
Published: Spandidos Publications 2022
Subjects:
adavosertib
Adavosertib
apoptosis
Apoptosis
Cell Line, Tumor
genetics
Head and Neck Neoplasms
Head and neck squamous cell carcinoma
head and neck tumor
human
Humans
hydroxamic acid
Hydroxamic Acids
Mitotic catastrophe
P53
protein p53
pyrazole derivative
Pyrazoles
pyrimidine derivative
Pyrimidines
pyrimidinone derivative
Pyrimidinones
ricolinostat
Ricolinostat
Squamous Cell Carcinoma of Head and Neck
tumor cell line
Tumor Suppressor Protein p53
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