Butyrate supplementation regulates expression of chromosome segregation 1‑like protein to reverse the genetic distortion caused by p53 mutations in colorectal cancer

Butyrate supplementation regulates expression of chromosome segregation 1‑like protein to reverse the genetic distortion caused by p53 mutations in colorectal cancer

The chromosome segregation 1‑like (CSE1L) protein, which regulates cellular mitosis and apoptosis, was previously found to be overexpressed in colorectal cancer (CRC) cells harboring mutations. Therefore, regulating CSE1L expression may confer chemotherapeutic effects against CRC. The gut microflora...

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Bibliographic Details
Main Authors: Chang, C.-C (Author), Chang, K.-W (Author), Huang, C.-J (Author), Kan, Y.-A (Author), Kao, W.-Y (Author), Ku, W.-C (Author), Lin, P.-Y (Author), Liu, C.-Y (Author), Su, H.-H (Author), Yang, R.-N (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
butyricicoccus pullicaecorum
chromosome segregation 1‑like
colorectal cancer
p53 tumor suppressor
short‑chain fatty acid
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