Microfluidic Squeezing Enables MHC Class I Antigen Presentation by Diverse Immune Cells to Elicit CD8+ T Cell Responses with Antitumor Activity

Microfluidic Squeezing Enables MHC Class I Antigen Presentation by Diverse Immune Cells to Elicit CD8+ T Cell Responses with Antitumor Activity

CD8+ T cell responses are the foundation of the recent clinical success of immunotherapy in oncologic indications. Although checkpoint inhibitors have enhanced the activity of existing CD8+ T cell responses, therapeutic approaches to generate Ag-specific CD8+ T cell responses have had limited succes...

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Bibliographic Details
Main Authors: Abdeljawad, T. (Author), An, H. (Author), Bernstein, H. (Author), Blagovic, K. (Author), Booty, M.G (Author), Chong, E. (Author), Chow, J. (Author), Gonzalez, J.T (Author), Heimann, M. (Author), Hlavaty, K.A (Author), How, E. (Author), Jacques, M.K (Author), Jensen, K.F (Author), Knoetgen, H. (Author), Langer, R. (Author), Liu, S. (Author), Loughhead, S.M (Author), Mao, S. (Author), Merino, A. (Author), Myint, M. (Author), Ozay, E.I (Author), Pomerance, L. (Author), Pryor, O. (Author), Sharei, A. (Author), Smith, C. (Author), Stockmann, A. (Author), Subramanya, D. (Author), Talarico, L. (Author), Tian, L. (Author), Trumpfheller, C. (Author), Umaña, P. (Author), Venkitaraman, A. (Author), Vicente-Suarez, I. (Author), Volk, K. (Author), von Andrian, U.H (Author), Yarar, D. (Author), Yee, C. (Author)
Format: Article
Language:English
Published: American Association of Immunologists 2022
Subjects:
adoptive transfer
Adoptive Transfer
animal
Animals
antigen presentation
Antigen Presentation
antigen presenting cell
Antigen-Presenting Cells
Antigens, Neoplasm
biological model
CD8+ T lymphocyte
CD8-Positive T-Lymphocytes
cell culture technique
Cell Culture Techniques
female
Female
Histocompatibility Antigens Class I
HLA antigen class 1
human
Humans
immunization
Immunization
immunology
immunophenotyping
Immunophenotyping
knockout mouse
Leukocytes, Mononuclear
Lymphocytes, Tumor-Infiltrating
metabolism
Mice
Mice, Knockout
microfluidics
Microfluidics
Models, Biological
mononuclear cell
mouse
neoplasm
Neoplasms
pathology
procedures
T lymphocyte subpopulation
T-Lymphocyte Subsets
tumor antigen
tumor associated leukocyte
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