Long non-coding RNA SPRY4-IT1 promotes proliferation and metastasis in nasopharyngeal carcinoma cell

Long non-coding RNA SPRY4-IT1 promotes proliferation and metastasis in nasopharyngeal carcinoma cell

Background. Long non-coding RNA SPRY4 intronic transcript 1 (Lnc RNA SPRY4-IT1) was aberrant-expressed in various kinds of cancer. Increasing evidence demonstrated that lnc RNAs involved in tumorigenesis and metastasis. In this study, we aimed to explore the biological role of SPRY4-IT1 on the pheno...

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Bibliographic Details
Main Authors: Chen, L. (Author), Deng, S. (Author), Feng, S. (Author), Li, Y. (Author), Liang, Z. (Author), Liao, Z. (Author), Lin, Z. (Author), Liu, Z. (Author), Wang, R. (Author)
Format: Article
Language:English
Published: PeerJ Inc. 2022
Subjects:
animal experiment
animal model
apoptosis
Article
cadherin
carcinogenesis
caspase 3
cell cycle
cell cycle arrest
cell invasion
cell migration
cell migration assay
cell proliferation
cell viability
colony formation
controlled study
cyclin B1
cyclin D1
cyclin dependent kinase 1
DNA damage
down regulation
epithelial mesenchymal transition
epithelium cell
female
flow cytometry
G2 phase cell cycle checkpoint
gene expression
genetic susceptibility
genetic transfection
heat stress
human
human cell
immunofluorescence
in vitro study
in vivo study
LncRNA SPRY4-IT1
long non coding rna spry4 intronic transcript 1
long untranslated RNA
Metastasis
mouse
Nasopharyngeal carcinoma
nasopharyngeal carcinoma cell line
nasopharynx carcinoma
nerve cell adhesion molecule
nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase
nonhuman
NP69SV40T cell line
phenotype
polymerase chain reaction
Proliferation
protein Bax
protein expression
protein function
protein processing
quantitative analysis
radiosensitivity
reverse transcription polymerase chain reaction
RNA extraction
RNA interference
small interfering RNA
snail
suppressor of cytokine signaling
transwell assay
tumor growth
Twist related protein 1
unclassified drug
upregulation
uvomorulin
vimentin
Western blotting
wound healing assay
xenograft
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