A rapid MCM-41 dispersive micro-solid phase extraction coupled with LC/MS/MS for quantification of ketoconazole and voriconazole in biological fluids

A rapid MCM-41 dispersive micro-solid phase extraction coupled with LC/MS/MS for quantification of ketoconazole and voriconazole in biological fluids

A rapid dispersive micro-solid phase extraction (D-μ-SPE) combined with LC/MS/MS method was developed and validated for the determination of ketoconazole and voriconazole in human urine and plasma samples. Synthesized mesoporous silica MCM-41 was used as sorbent in d-μ-SPE of the azole compounds fro...

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Bibliographic Details
Main Authors: Abd Aziz, N. (Author), Kamaruzaman, S. (Author), Loh, S.H (Author), Nur, H. (Author), Sanagi, M.M (Author), Wan Ibrahim, W.A (Author), Yahaya, N. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Ltd 2017
Subjects:
acetonitrile
ammonium acetate
antifungal agent
Antifungal Agents
Article
blood
blood sampling
body fluid
chemistry
Chromatography, High Pressure Liquid
desorption
dispersive micro-solid phase extraction
drug determination
drug isolation
economics
formic acid
high performance liquid chromatography
human
Humans
ketoconazole
Ketoconazole
LC/MS/MS
limit of detection
Limit of Detection
limit of quantitation
liquid chromatography
MCM-41
mesoporous silica nanoparticle
pH
procedures
pyrrole derivative
quadrupole mass spectrometry
silicon dioxide
Silicon Dioxide
sodium chloride
solid phase extraction
solid phase microextraction
Solid Phase Microextraction
tandem mass spectrometry
Tandem Mass Spectrometry
urine
urine sampling
validation study
voriconazole
Voriconazole
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